CCG-120304
CAS No. : 854005-84-8
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| Cat. No. : | HY-123448 |
| M.Wt: | 294.35 |
| Formula: | C19H18O3 |
| Purity: | >98 % |
| Solubility: |
CCG-120304 is a TonB system inhibitor and bacteriostatic agent. CCG-120304 inhibits TonB-dependent functions. CCG-120304 is applicable to research related to urinary tract infections[1].
In Vitro:CCG-120304 (0.39-100 μM; 16-20 h) inhibits growth of UPEC CFT073 ΔtolC::kan under iron-limiting conditions with an AC50 of 11 μM, acts as a bacteriostatic agent without disrupting proton motive force, and its inhibitory effect is reversed by excess iron[1].
CCG-120304 (0.39-100 μM; 16 h) specifically targets the TonB system in UPEC, as its growth inhibitory activity is abrogated in TonB-deficient strains and reversed by TonB overexpression[1].
CCG-120304 (100 μM; 20 min) inhibits TonB-dependent function in E. coli, as demonstrated by its ability to block irreversible adsorption of the TonB-dependent bacteriophage λh80 without affecting TonB-independent phage adsorption[1].
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