NVP-BAG956
CAS No. : 853910-02-8
(Synonyms: BAG 956)
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $270 | In-stock |
| 25mg | $540 | In-stock |
| 50mg | $900 | In-stock |
| 100mg | $1650 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13333 |
| M.Wt: | 427.50 |
| Formula: | C28H21N5 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
NVP-BAG956 is an ATP-competitive PI3K inhibitor with IC50s of 34, 56, 112 and 444 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively. IC50 & Target: IC50: 34 nM (PI3Kδ), 56 nM (PI3Kα), 112 nM (PI3Kγ), 444 nM (PI3Kβ), 240/260 nM (PDK1)[1] In Vitro: NVP-BAG956 also inhibits PDK1 with an IC50 of 240/260 nM. NVP-BAG956 also inhibits VEGFR1 with an IC50 of 2.56±0.56 μM. NVP-BAG956 blocks phosphorylation of PKB/Akt in A2058 cells with an IC50 value of 67±25 nM. Inhibition of PKB/Akt phosphorylation correlated with loss of A2058 cell proliferation for NVP-BAG956 (IC50=290±20 nM). In the presence of NVP-BAG956, A2058 cells are only able to exit G2-M and then remain in G1. The p27 Kip1 expression is clearly induced by NVP-BAG956 in A2058 cells but not in C32 cells[1].
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