BML-284
CAS No. : 853220-52-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $550 | In-stock |
| 200mg | $810 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-19987 |
| M.Wt: | 350.37 |
| Formula: | C19H18N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50?of 700 nM[1]. IC50 & Target: EC50: 700 nM (TCF-dependent transcriptional activity)[1] In Vitro: BML-284 (10 μM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen[1].BML-284 (10 μM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group[1]. In Vivo: BML-284 (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos[1].
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