Amosulalol
CAS No. : 85320-68-9
(Synonyms: YM 09538)
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| Cat. No. : | HY-106720 |
| M.Wt: | 380.46 |
| Formula: | C18H24N2O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR)[1].
In Vivo: Amosulalol (3-30 mg/kg; p.o.; single dose) reduces acute systolic blood pressure in hypertensive rats[1].
Amosulalol (50 mg/kg; p.o.; twice daily for 12 weeks) produces an intolerant antihypertensive effect and also reduces central rate and increases PRA in hypertensive rat models[1].
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