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TCN 201


CAS No. : 852918-02-6

852918-02-6
Price and Availability of CAS No. : 852918-02-6
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Cat. No. : HY-13457
M.Wt: 461.90
Formula: C21H17ClFN3O4S
Purity: >98 %
Solubility: DMSO : 250 mg/mL (ultrasonic)
Introduction of 852918-02-6 :

TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDA receptor, with a pIC50 of 6.8. TCN 201 is selective for GluN1/GluN2A NMDA receptor over GluN1/GluN2B NMDA receptor (pIC50<4.3)[1][2]. IC50 & Target: pIC50: 6.8 (GluN1/GluN2A NMDA receptor)[1] In Vitro: TCN 201 (compound 1) is selective for GluN1/GluN2A NMDAR over GluN1/GluN2B NMDAR, with pIC50s of 6.8 and <4.3, respectively[1].
TCN 201 (10 μM) produces only slight inhibition of GluN1/GluN2B NMDAR-mediated currents in oocytes[2].
TCN 201 (10-30 μM) antagonism of NMDAR-mediated responses is both subtype- and glycine-dependent and more potent than TCN 213 in oocytes[2].
TCN 201 (0.1-100 μM) does not produce complete block of NMDAR-mediated responses in oocytes[2].
TCN 201 (10 μM) antagonism of NMDAR-mediated currents shows a negative correlation with their ifenprodil sensitivity in rat cortical neurons[2].
TCN 201 (1-9 μM) suppresses cortical spreading depression (CSD) in chick retina[3]. In Vivo: TCN-201 (10 mg/kg; i.p.) is ineffective in CSD blood-oxygen level-dependent (BOLD) response in rats[4].

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