TP-808
CAS No. : 852821-06-8
| Size | Price | Stock |
|---|---|---|
| 100mg | $88 | In-stock |
| 250mg | $147 | In-stock |
| 1g | $394 | In-stock |
| 5g | $1399 | In-stock |
| 10 g | Get quote | |
| 50 g | Get quote | |
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| Cat. No. : | HY-13952 |
| M.Wt: | 482.64 |
| Formula: | C26H34N2O5Si |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
TP-808 is a key enone intermediate for the discovery and manufacture of Tetracycline (HY-A0107) analogs and synthetic tetracyclines including eravacycline[1]. In Vitro:TP-808 features highly modified stereocenters and functional groups (such as dimethylamino, TBS-protected phenoxy, benzyloxy, and isoxazole rings). It can rapidly construct the tetracyclic ABCD core skeleton of tetracyclines via Michael-Dieckmann condensation with a D-ring precursor, and serves as an essential building block for achieving "convergent total synthesis of tetracyclines and breaking through the bottleneck of semi-synthetic modification"[1].
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