(E)-MDL72274 (hydrochloride)


CAS No. : 85278-24-6

85278-24-6
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Cat. No. : HY-111290
M.Wt: 204.10
Formula: C9H11Cl2N
Purity: >98 %
Solubility:
Introduction of 85278-24-6 :

(E)-MDL72274 hydrochloride is a semicarbazide-sensitive amine oxidase (SSAO) inhibitor with an IC50 value of 0.74-1.42 μM. (E)-MDL72274 hydrochloride inhibits allylamine-induced excessive contraction of isolated coronary artery bypass graft vessels. (E)-MDL72274 hydrochloride can be used in studies related to vasospasm[1]. In Vitro:(E)-MDL72274 (1 nM-0.1 mM; 30 min) hydrochloride potently inhibits SSAO activity in homogenized human internal mammary artery, radial artery, and saphenous vein with IC50 values ranging from 0.74-1.42 μM, and completely blocks SSAO activity at 0.1 mM[1].
(E)-MDL72274 (0.1 mM; 20 min) hydrochloride completely blocks Allylamine-induced hypercontraction and associated vascular dysfunction in isolated human internal mammary artery rings by inhibiting SSAO activity[1].

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