Samidorphan
CAS No. : 852626-89-2
(Synonyms: ALKS-33; RDC-0313)
| Size | Price | Stock |
|---|---|---|
| 5mg | $425 | In-stock |
| 10mg | $680 | In-stock |
| 25mg | $1350 | In-stock |
| 50mg | $2150 | In-stock |
| 100mg | $3400 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-123689 |
| M.Wt: | 370.44 |
| Formula: | C21H26N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
Samidorphan (ALKS-33) is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo. Samidorphan can improve the behavior of depressed animals[1][2][3][4][5].
In Vivo:Samidorphan (10 mg/kg, p.o. for 2 weeks) significantly increases the activity of mice in the stress group[4].
Samidorphan (0-10 mg/kg, s.c., 3 h-1 week) can alter the behavior and extracellular neurotransmitter concentration of rats[5].
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