Necrostatin 2 (racemate)
CAS No. : 852391-15-2
(Synonyms: Necrostatin 1S; Nec-1S; 7-Cl-O-Nec1)
| Size | Price | Stock |
|---|---|---|
| 100mg | $165 | In-stock |
| 250mg | $346 | In-stock |
| 1g | $1039 | In-stock |
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| Cat. No. : | HY-14622A |
| M.Wt: | 277.71 |
| Formula: | C13H12ClN3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Necrostatin 2 racemate (Nec-1S), the Necrostatin-1 (HY-15760) stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect[1]. IC50 & Target:RIPK1[1] In Vitro:Necrostatin 2 racemate (Nec-1S) (1-100 μM; 1 h) potently inhibits RIPK1 autophosphorylation in a dose-dependent manner[1]. In Vivo:Necrostatin 2 racemate (Nec-1S) (6 mg/kg; i.v.; once) protects against TNF-induced systemic inflammatory response syndrome (SIRS) without sensitization effect[1].
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