Flt-3 Inhibitor III
CAS No. : 852045-46-6
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| Cat. No. : | HY-112475 |
| M.Wt: | 365.49 |
| Formula: | C21H23N3OS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Flt-3 Inhibitor III is a potent and selective FLT3 kinase inhibitor with an 50 of 50 nM. Flt-3 Inhibitor III shows less active against other kinases. Flt-3 Inhibitor III has anticancer effects[1].
IC50 & Target:IC50: 50 nM (FLT3 kinase)[1]
In Vitro:Flt-3 Inhibitor III (compound 4) also inhibits c-Kit, KDR, c-Abl, CDK1, c-Src and Tie-2 with IC50 values of 0.26 µM, 0.91 µM, 1.2 µM, 2.1 µM, 2.8 µM, and 8.0 µM, respectively[1].
Flt-3 Inhibitor III (compound 4) blocks the proliferation of BaF3-ITD, BaF3-D835/Y, and MV4:11 cells, with IC50 values of 0.24 µM, 0.76 µM, and 0.052 µM, respectively[1].
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