PF-376304


CAS No. : 851757-93-2

851757-93-2
Price and Availability of CAS No. : 851757-93-2
Size Price Stock
100 mg Get quote
250 mg Get quote
500 mg Get quote
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-107387
M.Wt: 388.43
Formula: C17H24N8O3
Purity: >98 %
Solubility:
Introduction of 851757-93-2 :

PF-376304 is an orally active non-specific class I phosphoinositide 3-kinase (PI3K) inhibitor with an IC50 of 0.197 μM against PI3Kγ. PF-376304 induces dose-dependent glucose and lipid metabolic disorders in rats, causes rapid death at high doses, and leads to metabolic abnormalities that are self-reversible at low doses. PF-376304 is applicable to the research of metabolic and inflammatory diseases[1][2]. In Vivo:PF-376304 (0-1000 mg/kg; i.g.; 7 d) induces significant and reversible glucose metabolism disorders, ketonuria and creatinuria in Sprague-Dawley rats, while doses of ≥300 mg/kg cause rapid death within 72 h[1].

Your information is safe with us.