Zatebradine
CAS No. : 85175-67-3
(Synonyms: UL-FS-49 (free base); UL-FS-49CL (free base))
| Size | Price | Stock |
|---|---|---|
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| 10mg | $135 | In-stock |
| 50mg | $588 | In-stock |
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| Cat. No. : | HY-13422A |
| M.Wt: | 456.57 |
| Formula: | C26H36N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL;Ethanol : 100 mg/mL (ultrasonic) |
Zatebradine (UL-FS-49 (free base); UL-FS-49CL (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 value of 1.96 µM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively[1]. IC50 & Target: IC50: 1.96 µM (HCN channels)[1] In Vitro: The use-dependent blockade by Zatebradine of the cardiac pacemaker current from rabbit sino-atrial node cells has an apparent Kd of 480 nM[2]. In Vivo: Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes; male C57/Bl6-mice) reduces the heart rate dose-dependently from 600 to 200 bpm with ED50 value of 1.8 mg/kg and induces increasing arrhythmia[1].
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