ELN318463
CAS No. : 851600-86-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $800 | In-stock |
| 10mg | $1300 | In-stock |
| 50mg | $3500 | In-stock |
| 100mg | $4900 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-50882 |
| M.Wt: | 471.80 |
| Formula: | C19H20BrClN2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1[1][2]. IC50 & Target: EC50: 12 nM (PS1 γ-secretase), 656 nM (PS2 γ-secretase)[1] In Vitro: ELN318463 behaves as a classic γ-secretase inhibitor, demonstrates 75- to 120-fold selectivity for inhibiting Aβ production compared with Notch signaling in cells, and displaces an active site directed inhibitor at very high concentrations only in the presence of substrate[2]. In Vivo: ELN318463 (30 mg/kg or 100 mg/kg; orally) leads acute reduction of brain Aβ in in the PDAPP transgene model of Alzheimer's disease (AD) as well as in wild-type FVB strain mice[2].
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