PSI-697
CAS No. : 851546-61-7
(Synonyms: P-Selectin Inhibitor)
| Size | Price | Stock |
|---|---|---|
| 1mg | $168 | In-stock |
| 5mg | $420 | In-stock |
| 10mg | $600 | In-stock |
| 50mg | $1800 | In-stock |
| 100mg | $2520 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15526 |
| M.Wt: | 367.83 |
| Formula: | C21H18ClNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 45.8 mg/mL |
PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM[1].
IC50 & Target: IC50: 125 μM (P-selectin)[1]
In Vitro: PSI-697 inhibits the binding of a soluble human P-selectin to PSGL-1, in a reproducible concentration-dependent manner inhibiting 50% of binding at a concentration of 125 μM in vitro[1].
In Vivo: PSI-697 (0-50 mg/kg; p.o.) significantly reduces the number of rolling leukocytes by 39% versus vehicle control[1].
PSI-697 (100 mg/kg; p.o.) reduces thrombus weight by 18% relative to vehicle, without prolonging bleeding time in a rat venous thrombosis model[1].
PSI-697 (30 mg/kg; p.o.; daily; 6 days) promotes thrombus resolution and decreases inflammation in a baboon model of venous thrombosis[2].
PSI-697 ((30 mg/kg; i.g.; daily) decreases vein wall injury in a rat stenosis model of venous thrombosis[2].
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