Hydronidone
CAS No. : 851518-71-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $520 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100438 |
| M.Wt: | 201.22 |
| Formula: | C12H11NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
Hydronidone is an orally active pyridine derivative. Hydronidone is an inhibitor of phosphodiesterase-4 (PDE4) and cyclo-oxygenase (COX) as well as TGF-β. Hydronidone induces mitochondrial dysfunction and triggers apoptosis. Hydronidone can be used for liver fibrosis, anti-inflammation and anti-cancer study[1][2][3].
In Vitro:Hydronidone (200-400 μM) inhibits the activation of hepatic stellate cells (HSCs) and inhibits liver fibrosis through regulation of Smad7 expression[1].
Hydronidone (400 μM) promotes TGFβRI degradation through Smad7 in a ubiquitin-proteasome-dependent pathway in HSCs[1].
Hydronidone (400 μM, 24 h) significantly promotes apoptosis in activated hepatic stellate cells (aHSCs) through mitochondrial (intrinsic) pathway in LX-2 cells[2].
Hydronidone (400 μM, 24 h) triggers endoplasmic reticulum stress (ERS) and subsequently activated the IRE1α-ASK1-JNK pathway[2].
In Vivo:Hydronidone (50-100 mg/kg; p.o.) ameliorates CCl4-induced and DDC-induced liver fibrosis and hepatic injury in mice[1].
Hydronidone significantly promotes apoptosis in activated hepatic stellate cells (aHSCs) in the CCl4- and DDC-induced liver fibrosis in mice[2].
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