AZ12253801
CAS No. : 851432-37-6
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| Cat. No. : | HY-125102 |
| M.Wt: | 402.45 |
| Formula: | C21H22N8O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ～10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R-driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50?for epidermal growth factor receptor (EGFR)-driven proliferation is 440 nmol/L. Anti-tumor activity.
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