2-(Phenylethynyl)-ATP
CAS No. : 851265-78-6
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| Cat. No. : | HY-107752 |
| M.Wt: | 607.30 |
| Formula: | C18H20N5O13P3 |
| Purity: | >98 % |
| Solubility: |
2-(Phenylethynyl)-ATP is an analog of ATP (HY-B2176). 2-(Phenylethynyl)-ATP can generate an AdoMet (HY-B0617) analog (2-(phenylethynyl)-AdoONB). 2-(phenylethynyl)-AdoONB derived from 2-(Phenylethynyl)-ATP shows no activity against methyltransferases NovO, RnCOMT-var and GlaTgs2-var[1].
In Vitro:2-(phenylethynyl)-ATP (Compound o1) (2.5 mM; 6 h) mediates mediocr conversion of ortho-nitrobenzyl-DL-homocysteine by PC-MjMAT, with negligible conversion of propargyl-L-selenohomocysteine, and the resulting 2-(phenylethynyl)-AdoONB product forms strong van der Waals interactions with PC-MjMAT that suggest product inhibition[1].
2-(phenylethynyl)-ATP (2.5 mM; 6 h) supports minimal NovO-mediated THPC modification via ortho-nitrobenzyl group transfer and negligible propargyl group transfer in PC-MjMAT/MTase cascade reactions[1].
2-(phenylethynyl)-ATP (2.5 mM; 6 h) does not support measurable RnCOMT-var-mediated DHBAL modification via either ortho-nitrobenzyl or propargyl group transfer in PC-MjMAT/MTase cascade reactions[1].
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