STX-0119
CAS No. : 851095-32-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $72 | In-stock |
| 10mg | $116 | In-stock |
| 25mg | $234 | In-stock |
| 50mg | $371 | In-stock |
| 100mg | $560 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-103692 |
| M.Wt: | 382.37 |
| Formula: | C22H14N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 13.33 mg/mL (ultrasonic;warming;heat to 60°C) |
STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM[1].
In Vitro:STX-0119 (10-50 μM; 24 h) inhibits STAT3 dimerization through a direct interaction with the STAT3 protein and not via the modulation of upstream regulators such as JAK in HEK293 and MDA-MB-468 cells[1].
STX-0119 (10-50 μM; 24 h) reduces the expression of STAT3 target proteins[1].
In Vivo:STX-0119 (160 mg/kg; oral gavage; daily for 4 days) inhibits SCC-3 tumor growth in mice[1].
The plasma concentration of STX-0119 (160 mg/kg; oral gavage) is maintained at >100 μg/mL (>260 μM), even at 8 h after administration[1].
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