Alogliptin
CAS No. : 850649-61-5
(Synonyms: SYR-322 (free base))
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $72 | In-stock |
| 50mg | $120 | In-stock |
| 100mg | $171 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-A0023A |
| M.Wt: | 339.40 |
| Formula: | C18H21N5O2 |
| Purity: | >98 % |
| Solubility: | H2O : 10 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 100 mg/mL (ultrasonic) |
Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes[1][2][3].
IC50 & Target: IC50: <10 nM (DPP-4)[1]
In Vitro: Alogliptin (1 nM; 5-60 min) inhibits LPS-induced extracellular signal-regulated kinase (ERK) phosphorylation in U937 cells[2].
Alogliptin (0.5-5 nM; 24 h) inhibits LPS-stimulated MMP-1 secretion and mRNA expression that is mediated by ERK pathway in U937 cells[2].
In Vivo: Alogliptin (0.01-1 mg/kg; p.o.) produced dose-dependent improvements in glucose tolerance and increased plasma insulin levels in female Wistar fatty rats[1].
Alogliptin (40 mg/kg/day for 2 weeks; p.o.) reduces infarction area and improves brain vascular integrity in middle cerebral artery occlusion (MCAO) mice[3].
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