ML604086
CAS No. : 850330-18-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $75 | In-stock |
| 5mg | $170 | In-stock |
| 10mg | $270 | In-stock |
| 25mg | $490 | In-stock |
| 50mg | $690 | In-stock |
| 100mg | $970 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-124416 |
| M.Wt: | 508.63 |
| Formula: | C27H32N4O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 120 mg/mL (ultrasonic) |
ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations[1][2].
IC50 & Target: CCR8[1][2].
In Vitro: ML604086 (0-100 µM) inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations of cell lines stably expressing cyno CCR8 with IC50s of 1.3 µM and 1.0 µM, respectively[2].
ML604086 (10, 30 µM; 64 h) inhibits CCL1 binding to CCR8 on CD4 T-cells, and inhibits the serotonin receptor 5HT1a with the inhibition rate of 30%, 70% at 10, 30 µM respectively[2].
In Vivo: ML604086 (1.038 mg/kg; intravenous infusion) shows no effect on airway eosinophilia, pro-inflammatory cytokine production or airway resistance and compliance in Macaca fascicularis[1].
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