cGAMP
CAS No. : 849214-04-6
(Synonyms: Cyclic GMP-AMP; 3',3'-cGAMP)
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| 1mg | $330 | In-stock |
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| Cat. No. : | HY-12512 |
| M.Wt: | 674.41 |
| Formula: | C20H24N10O13P2 |
| Purity: | >98 % |
| Solubility: | H2O : 180 mg/mL (ultrasonic) |
cGAMP (Cyclic GMP-AMP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].
IC50 & Target:Endogenous Metabolite
In Vitro:cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice[2].
cGAMP directly activates murine and human dendritic cells in vitro[2].
On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF)[3].
cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs[4].
In Vivo:cGAMP (5 μg; nostril mucosal adjuvant) promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].
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