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|---|---|---|
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| Cat. No. : | HY-18211 |
| M.Wt: | 445.58 |
| Formula: | C23H31N3O4S |
| Purity: | >98 % |
| Solubility: |
CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC50s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1)- and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats[1]. IC50 & Target:IC50: 55 nM (ECE-1), 2 nM (NEP), 22 nM (ACE)
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