HSDVHK-NH2
CAS No. : 848644-86-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $125 | In-stock |
| 10mg | $190 | In-stock |
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| Cat. No. : | HY-P1187 |
| M.Wt: | 720.78 |
| Formula: | C30H48N12O9 |
| Purity: | >98 % |
| Solubility: | H2O : 250 mg/mL (ultrasonic) |
HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM)[1][2].
In Vitro: HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group[1].
The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC50 value of 25.72 nM[2].
HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression[3].
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