A-582941 (dihydrochloride)
CAS No. : 848591-90-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $680 | In-stock |
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| Cat. No. : | HY-59201A |
| M.Wt: | 353.29 |
| Formula: | C17H22Cl2N4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
A-582941 dihydrochloride is a selective, orally active, blood-brain barrier-permeable α7 nAChR agonist, with Ki values of 10.8 nM and 17 nM in rat brain and human frontal cortex, respectively. A-582941 dihydrochloride exhibits agonistic activity at 5-HT3 receptors, with a Ki of 150 nM. A-582941 dihydrochloride triggers phosphorylation of ERK1/2 and CREB, inhibits GSK-3β via Ser-9 phosphorylation, increases acetylcholine release, induces the expression of Arc and c-Fos, activates brain regions associated with working memory and attention, and reduces cell death caused by nerve growth factor (NGF) deprivation. A-582941 dihydrochloride is applicable for the research of Alzheimer's disease and schizophrenia[1][2][3].
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