Alvelestat
CAS No. : 848141-11-7
(Synonyms: AZD9668)
| Size | Price | Stock |
|---|---|---|
| 1mg | $36 | In-stock |
| 5mg | $77 | In-stock |
| 10mg | $110 | In-stock |
| 50mg | $330 | In-stock |
| 100mg | $495 | In-stock |
| 200mg | $750 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-15651 |
| M.Wt: | 545.53 |
| Formula: | C25H22F3N5O4S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 33 mg/mL |
Alvelestat (AZD9668) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM[1]. IC50 & Target: pIC: 7.9 nM; Ki: 9.4 nM; Kd: 9.5 nM (neutrophil elastas)[1] In Vitro: Alvelestat (20 μg/mL; 16 hours; HBE and A549 cells) treatment decreases cells death and decreases the levels of IL-1β, IL-6, and TNF-α in vitro[2]. In Vivo: Alvelestat (1-10 mg/kg; oral administration; twice daily; for 4 days; Female BALB/cJBomTac mice) treatment reduces the inflammatory response to cigarette smoke as indicated by a reduction in BAL neutrophils and interleukin-1β[1].
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