Norgestrienone

Cat. No. :	HY-111302
M.Wt:	294.39
Formula:	C20H22O2
Purity:	>98 %
Solubility:	10 mM in DMSO

Introduction of 848-21-5 :

Norgestrienone is an orally active 19‑norprogestogen. Norgestrienone is a synthetic steroid that acts as an agonist of the Progesterone Receptor. Norgestrienone can be used in research related to male hormonal contraception^[1][2].

In Vitro:Norgestrienone exhibits a moderate gradual decreasing trend in release rate over 365‑day in‑vitro release from silicone rubber capsules, and the initial steroid loading inside the capsule exerts minimal effect on its release rate^[1]. In Vivo:Norgestrienone (single‑capsule implantation; 56‑358 days) shows a gradual decline in mean daily release rate per cm of capsule length from 23.0 μg/cm/day at day 56 to 13.7 μg/cm/day at day 358 when released from subcutaneously‑implanted Silastic capsules in Rattus norvegicus^[1].
Norgestrienone (47 mg per silicone rubber capsule; 1-4 capsules) exhibits a dose-dependent contraceptive effect in implant-related studies; implantation of 4 capsules provides contraceptive protection for at least 12-13 months^[2].