O-Desmethyl gefitinib
CAS No. : 847949-49-9
Price and Availability of
CAS No. : 847949-49-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $76 | In-stock |
| 250mg | $958 | In-stock |
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| Cat. No. : | HY-100064 |
| M.Wt: | 432.88 |
| Formula: | C21H22ClFN4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Introduction of
847949-49-9
:
O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2]. IC50 & Target:IC50: 36 nM (EGFR)[2]
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