AAT-008
CAS No. : 847727-81-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $210 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $720 | In-stock |
| 100mg | $1150 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-122168 |
| M.Wt: | 414.81 |
| Formula: | C21H16ClFN2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
AAT-008 is a potent, selective, and orally active prostaglandin EP4 receptor antagonist with Kis of 0.97 and 6.1 nM for recombinant human EP4 and recombinant rat EP4, respectively. AAT-008 exerts tumor growth delay in mice bearing CT26WT colon tumors when combined with radiotherapy. AAT-008 can be used for the study of acute and chronic inflammatory pain and cancer
[1][2].
In Vivo:AAT-008 (1 mg/kg, p.o., once) significantly reduces Carrageenan (HY-125474) and Complete Freund’s adjuvant (CFA) (HY-153808B)-induced mechanical hyperalgesia in rats[1].
AAT-008 (3-30 mg/kg, p.o., once or twice daily, up to 18 days) exerts tumor growth delay in Balb/c mice bearing CT26WT colon tumors alone or combined with radiotherapy[2].
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