SHA 68
CAS No. : 847553-89-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $103 | In-stock |
| 10mg | $165 | In-stock |
| 25mg | $330 | In-stock |
| 50mg | $528 | In-stock |
| 100mg | $845 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-108625 |
| M.Wt: | 445.49 |
| Formula: | C26H24FN3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia[1][2].
IC50 & Target: IC50: 22 nM (Asn107) and 23.8 nM (Ile107)[1]
In Vivo: SHA 68 (i.p.; 5 and 50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing[1].
SHA 68 (i.v.; 1 mg/kg) has a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg[1].
SHA 68 (i.p.; 2.5 mg/kg) has a T1/2 of 0.43 hours, a CL of 4.56 mL/min/kg[1].
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