UVI 3003
CAS No. : 847239-17-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $88 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $310 | In-stock |
| 50mg | $520 | In-stock |
| 100mg | $850 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-107500 |
| M.Wt: | 436.58 |
| Formula: | C28H36O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively. IC50 & Target: IC50: 0.22 μM (Xenopus RXRα, in Cos7 cells), 0.24 μM (Human RXRα, in Cos7 cells)[1] In Vitro: UVI3003 inhibits the activity of xenopus and human RXRα, with IC50s of 0.22 and 0.24 μM, respectively. UVI3003 fully activates xPPARγ with an EC50 of 12.6 μM, and is almost completely inactive on hPPARγ and mPPARγ[1]. UVI 3003 (10 μM) does not change the proliferation rate of extraocular muscles (EOM)-derived or LEG-derived EECD34 cells. UVI 3003 causes a 65.4% difference in EECD34 cell fusion and desmin expression[2].
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