BF 227
CAS No. : 845647-80-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $680 | In-stock |
| 25mg | $1350 | In-stock |
| 50mg | $2200 | In-stock |
| 100mg | $3500 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-105252A |
| M.Wt: | 333.38 |
| Formula: | C16H16FN3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils. IC50 & Target: Ki: 4.3 nM (Aβ1-42)[1]. In Vitro: BF-227 has a high binding affinity for Aβ1-42 fibrils. The Ki value for Aβ1-42 fibrils in competitive binding assay using [125I]BF-180 is 4.3±1.3 nM in BF-227 (Kd value of [125I]BF-180: 10.8±1.5 nM)[1]. [11C]BF-227 is a PET tracer. The AUC for BF-227 (0.994) is much higher than that for FDG (0.839), indicating that BF-227 is more sensitive as well as more specific than FDG in diagnosing AD[2].
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