Boc-C14-COOH


CAS No. : 843666-27-3

843666-27-3
Price and Availability of CAS No. : 843666-27-3
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1g $12 In-stock
5g $32 In-stock
10g $60 In-stock
25g $133 In-stock
100g $523 In-stock
500g $1699 In-stock
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Cat. No. : HY-W034599
M.Wt: 342.51
Formula: C20H38O4
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 843666-27-3 :

Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. In Vitro:ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

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