Eticlopride
CAS No. : 84226-12-0
(Synonyms: FLB-131)
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| Cat. No. : | HY-121129 |
| M.Wt: | 340.85 |
| Formula: | C17H25ClN2O3 |
| Purity: | >98 % |
| Solubility: |
Eticlopride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with Kis of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride is an antipsychotic agent[1].
In Vitro:Eticlopride (1 μM, 6 h) abrogates the action of DA, where DA increases KLF2 expression in HUVEC cells[2].
Eticlopride (1 μM, 15 min) abolishes heterodimerization of D2R/SSTR2 in rat striatal neurons[3].
In Vivo:Eticlopride (10 mg/kg, i.p.) blocks normal vessel morphologyc restored by DA in orthotopic PC3 and HT29 tumor-bearing animals[2].
Eticlopride (0.01 or 0.02 mg/kg, i.p.) alleviates cognitive deficits produced by Quinpirole (HY-B1752) in rats[4].
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