AKT Kinase Inhibitor


CAS No. : 842148-40-7

842148-40-7
Price and Availability of CAS No. : 842148-40-7
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5mg $420 In-stock
10mg $720 In-stock
25mg $1120 In-stock
50mg $1500 In-stock
100mg $2000 In-stock
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Cat. No. : HY-10249A
M.Wt: 357.37
Formula: C16H19N7O3
Purity: >98 %
Solubility: DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 842148-40-7 :

AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1]. In Vitro: The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion[1]. In Vivo: Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus[1].

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