Trifenagrel
CAS No. : 84203-09-8
| Size | Price | Stock |
|---|---|---|
| 10mg | $70 | In-stock |
| 25mg | $140 | In-stock |
| 50mg | $220 | In-stock |
| 100mg | $350 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-105872 |
| M.Wt: | 383.49 |
| Formula: | C25H25N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 36 mg/mL (ultrasonic) |
Trifenagrel is an orally active platelet aggregation inhibitor that inhibits the inducing effects of arachidonic acid (AA) and collagen. The ED50s of trifenagrel for inhibiting AA- and collagen-induced platelet aggregation in guinea pigs were 1.4 mg/kg and 9.4 mg/kg, respectively[1].
In Vivo:When Trifenagrel is administered p.o. to guinea pigs, there is a sustained (greater than 3 hr) inhibition of AA- and collagen-induced platelet aggregation ex vivo (1 hr ED50 = 1.4 and 9.4 mg/kg, respectively)[1].
Trifenagrel appears to be a reversible inhibition of platelet AA cyclooxygenase. Doses of Trifenagrel up to 100 mg/kg p.o. in rats and guinea pigs inhibited gastric mucosal AA cyclooxygenase but does not produce the gastric damage[1].
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