Xanthoxyletin
CAS No. : 84-99-1
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| Cat. No. : | HY-N1065 |
| M.Wt: | 258.27 |
| Formula: | C15H14O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation[1][2]. In Vitro:Xanthoxyletin (1-500 µM; 30 min) inhibits DPPH radical with IC50 values of 247.1 μM and 63.8 μg/mL, and also shows a ferric reducing antioxidant power (FRAP) value of 45.2 µM[2]. Xanthoxyletin (10-500 µM; 24 h) shows cytotoxicity against HepG2, HCT116 and SK-LU-1 cancer cells with IC50 values of 78.2, 79.8 and 94.4 μM, respectively[2]. Xanthoxyletin (78 and 156 μM; 12 and 24 h) induces cell apoptosis and causes low necrosis[2].
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