Ataprost
CAS No. : 83997-19-7
(Synonyms: ONO 41483)
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| Cat. No. : | HY-119860 |
| M.Wt: | 348.48 |
| Formula: | C21H32O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ataprost (ONO 41483) is an orally active Carboprostacyclin (HY-112322) analogue. Ataprost exhibits 2.6 times more active than Carboprostacyclin in inhibiting ADP-induced platelet aggregation in vitro. Ataprost has the ability to relieve coronary spasm[1].
IC50 & Target:Platelet aggregation[1]
In Vitro:Ataprost inhibits platelet aggregation in human and baboon platelet rich plasma (PRP) with ED50s of 1.91 ng/mL and 4.38 ng/mL, respectively[1].
In Vivo:Ataprost (50-200 μg/kg; p.o.; single dose) inhibits platelet aggregation with an ED50 value of 87 μg/kg in baboon[1].
Ataprost (i.v.; single dose) inhibits platelet aggregation with an ED50 value of 3.2 μg/kg in baboon[1].
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