Pluripotin
CAS No. : 839707-37-8
(Synonyms: SC1)
| Size | Price | Stock |
|---|---|---|
| 2mg | $55 | In-stock |
| 5mg | $77 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $198 | In-stock |
| 50mg | $308 | In-stock |
| 100mg | $495 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-10579 |
| M.Wt: | 550.54 |
| Formula: | C27H25F3N8O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Pluripotin is a dual inhibitor of ERK1 and RasGAP with KDs of 98 nM and 212 nM, respectively. Pluripotin also inhibits RSK1, RSK2, RSK3, and RSK4 with IC50s of 0.5, 2.5, 3.3, and 10.0 µM, respectively. In Vitro: Pluripotin (SC-1) inhibits Abl1, p70S6K, PLK2, RSK1, RSK2, RSK3, RSK4 with IC50s of 0.005, 1.4, 2.2, 0.5, 2.5, 3.3, 10.0 µM,respectively. Pluripotin (SC-1) decreases cell growth for 7 colon tumor cell lines. After a five day exposure to 0.1 µM SC-1, the seven colon tumor lines are evaluated for changes in cell number and viability. There is a statistically significant decrease in cell number but >95% viability[2].
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