Fexofenadine


CAS No. : 83799-24-0

(Synonyms: MDL-16455; Terfenadine carboxylate)

83799-24-0
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Cat. No. : HY-B0801
M.Wt: 501.66
Formula: C32H39NO4
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 83799-24-0 :

Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3]. In Vitro:Fexofenadine (1-100 µM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner[2].
Fexofenadine (1-100 µM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK[2]. In Vivo:Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis[1].

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