Tertatolol
CAS No. : 83688-84-0
(Synonyms: (±)-Tertatolol; Racemic Tertatolol; dl-Tertatolol)
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| Cat. No. : | HY-U00356 |
| M.Wt: | 295.44 |
| Formula: | C16H25NO2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tertatolol is a potent antagonist of beta-adrenoceptor and 5-HT receptor, with unique renal vasodilatatory effects. In Vitro: In serum-free media, tertatolol does not significantly alter the incorporation of 3H-thymidine after 28 h of incubation in human mesangial cell (HMC). In the presence of 1% serum, tertatolol significantly reduces 3H-thymidine incorporation. Tertatolol also inhibits 3H incorporation when PDGF and thrombin are used as the stimulus. Tertatolol inhibits the reduction in planar surface area of HMC induced by angiotensin II. The inhibitory effect of tertatolol on HMC proliferation is also potentiated by ritanserin and MDL 72222, 5HT2 and 5HT3 antagonists, respectively[1].
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