α-CGRP (mouse, rat)
CAS No. : 83651-90-5
(Synonyms: CGRP (83-119), mouse, rat)
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| Cat. No. : | HY-P0203 |
| M.Wt: | 3806.25 |
| Formula: | C162H262N50O52S2 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 100 mg/mL |
α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies[1][2][3][4].
In Vitro: α-CGRP (mouse, rat) can regulate the innate lymphoid cell response in 2 groups[1].
α-CGRP (mouse, rat) regulates insulin secretion and reduces the risk of type 2 diabetes[2].
In Vivo: α-CGRP (mouse, rat) (0.25, 0.5, 1 μg/kg/min, intravenous) dose-dependent decreases mean arterial blood pressure, while heart rate and systemic vascular conduction increased, while cardiac output remained unchanged[3].
α-CGRP (mouse, rat) plays an important role in the regulation of Kainic acid (KA) induced pyramid-cell death in hippocampal CA3 region[4].
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