Spirapril
CAS No. : 83647-97-6
(Synonyms: SCH 33844)
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| Cat. No. : | HY-A0230 |
| M.Wt: | 466.61 |
| Formula: | C22H30N2O5S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Spirapril is a potent and cross the blood-brain barrier angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active prodrug of Spiraprilat and can be used for the research of hypertension, congestive heart failure[1][2][3].
In Vivo: Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice[2].
Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice[2].
Spirapril can crosses the blood-brain barrier and suppresses the transgene effect in the experiments[2].
Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats[3].
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