GLX351322


CAS No. : 835598-94-2

835598-94-2
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Cat. No. : HY-100111
M.Wt: 431.51
Formula: C21H25N3O5S
Purity: >98 %
Storage: at 20℃ 2 years
Solubility: DMSO
Introduction of 835598-94-2 :

GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μ M. IC50 & Target: IC50: 5 μ M (NOX4, cell assay), 40 μM (NOX2, cell assay)[1] In Vitro: GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells (IC50, 40 μM). In Vivo: GLX351322 (3.8 mg/kg/day, p.o.) ameliorates HFD-induced hyperglycemia in mice[1].

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