Nefazodone
CAS No. : 83366-66-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $68 | In-stock |
| 10mg | $106 | In-stock |
| 25mg | $222 | In-stock |
| 50mg | $343 | In-stock |
| 100mg | $525 | In-stock |
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| Cat. No. : | HY-119209 |
| M.Wt: | 470.01 |
| Formula: | C25H32ClN5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Nefazodone is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT2A receptors, and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of drug-drug interaction[1][2][3].
IC50 & Target:5-HT receptor, Noradrenaline, CYP3A4[1]
In Vitro:Nefazodone collapses mitochondrial membrane potential, and imposes oxidative stress, as detected via glutathione depletion, leading to cell death[2].
Nefazodone (200 μM; 24 h) depletes 100% of ATP in both, glucose and galactose-grown HepG2 cells[2].
Nefazodone (6.25, 12.5 and 25 μM; 0-120 min) profoundly inhibits oxygen consumption (OCR) in HepG2[2].
In Vivo:Nefazodone (10 mg/kg; s.c.; for 16 days) is effective to counter the adverse effects of stress on the the immune system of mice[3].
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