2OH-BNPP1
CAS No. : 833481-73-5
| Size | Price | Stock |
|---|---|---|
| 2mg | $132 | In-stock |
| 5mg | $238 | In-stock |
| 10mg | $422 | In-stock |
| 25mg | $871 | In-stock |
| 50mg | $1135 | In-stock |
| 100mg | $1475 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-102081 |
| M.Wt: | 297.35 |
| Formula: | C16H19N5O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer. IC50 & Target: BUB1 kinase[1] In Vitro: 2OH-BNPP1 (0.1-50 μM) abrogates TGFβ signaling in a dose dependent manner. 2OH-BNPP1 dose-dependently impairs the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines and normal cell lines[1]. In Vivo: 2OH-BNPP1 (50 mg/kg) blocks TGFβ signaling in vivo, and significantly decreases abundance of phosphorylated SMAD2 in tumor-bearing mice[1].
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