116-9e
CAS No. : 831217-43-7
(Synonyms: MAL2-11B)
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $800 | In-stock |
| 100mg | $1250 | In-stock |
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| Cat. No. : | HY-116683 |
| M.Wt: | 512.60 |
| Formula: | C31H32N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70[1][2].
IC50 & Target: Simian Virus 40 (SV40) [1]
Hsp70 co-chaperone DNAJA1[2]
In Vitro: 116-9e (MAL2-11B) inhibits TAg stimulation of Hsp70 with greater efficacy than MAL3-101, significantly reduces viral replication and DNA synthesis. MAL2-11B also inhibits the activity of the TAg ATPase domain[1].
116-9e (MAL2-11B; 15 µM; 5 days) significantly reduces the growth of BK virus in a human kidney cell line[1].
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