1-Naphthyl acetate

1-Naphthyl acetate is an attractive chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity. 1-Naphthyl acetate has the potential to detect organophosphorus pesticide (OP) poisoning^[1]. IC50 & Target:AChE^[1] In Vitro:1-Naphthyl acetate can be hydrolyzed by AChE into 1-Naphthol (HY-Y1309) and Acetic acid (HY-Y0319). 1-Naphthol can react with colorimetric reagents (such as Fast Blue RR (HY-W127771)) to generate colored products, which can be used for colorimetric analysis to quantitatively measure the activity of AChE^[1].
1-Naphthyl acetate be used for quick detection of organophosphorus pesticide (OP) poisoning, that OP inhibits the activity of AChE, resulting in reduced hydrolysis of 1-Naphthyl acetate^[1].
1-Naphthyl acetate can be hydrolyzed by intracellular esterases in plants cells to release acetic acid and 1-naphthol, leading to acidification of the extracellular medium. Acidification of the extracellular medium is considered to be one of the key factors in cell elongation. The acidified medium activates the proton pump on the cytoplasmic membrane, thereby promoting proton efflux and further reducing the cytoplasmic pH. The reduced cytoplasmic pH can activate the expansins in the cell wall, leading to cell wall relaxation, thereby promoting cell elongation^[2].