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Rotenone


CAS No. : 83-79-4

83-79-4
Price and Availability of CAS No. : 83-79-4
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500mg $50 In-stock
1g $60 In-stock
5g $108 In-stock
10g $173 In-stock
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Cat. No. : HY-B1756
M.Wt: 394.42
Formula: C23H22O6
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic)
Introduction of 83-79-4 :

Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. In Vitro:Mitogen Activated Protein Kinase (MAPK), Toll-like receptor, Wnt, and Ras signaling pathways are intensively involved in the effect of rotenone on the ENS[2]. In Vivo:Rotenone can be used to create Parkinson's disease models.

Induction of Parkinson's model[6]
Background
Cell loss of dopaminergic (DA) neurons in the substantia nigra is a common feature of Parkinson's disease. Rotenone induces DA neuronal cytotoxicity, leading to motor deficits in the substantia nigra and loss of DA neuronal cells in mice.
Specific Mmodeling Methods
Mice: male • C57BL/6J mice • 8 weeks old • 20-25 g
Administration: 30 mg/kg in 12 mL/kg • po • once daily for 28 days
Note
The control group was treated with 0.5% Carboxylmethylcellulose (CMC).
Modeling Indicators
Mouse dyskinesia: slow movement/inadequate movement ability.
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