Diiodohydroxyquinoline
CAS No. : 83-73-8
(Synonyms: Iodoquinol; 5,7-Diiodo-8-hydroxyquinoline; 5,7-Diiodo-8-quinolinol)
| Size | Price | Stock |
|---|---|---|
| 500mg | $50 | In-stock |
| 1g | $60 | In-stock |
| 5g | $90 | In-stock |
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| Cat. No. : | HY-B1400 |
| M.Wt: | 396.95 |
| Formula: | C9H5I2NO |
| Purity: | >98 % |
| Solubility: | DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 60°C);H2O : < 0.1 mg/mL |
Diiodohydroxyquinoline (Iodoquinol, 5,7-Diiodo-8-hydroxyquinoline, 5,7-Diiodo-8-quinolinol) has an orally active and satisfactory antiparasitic properties. Diiodohydroxyquinoline exhibits mutagenic potential in mice and potent anti-SARS-CoV-2 activity with an EC50 value of 1.38 μM in VeroE6 cells. Diiodohydroxyquinoline's antimutagen is ascorbic acid. Diiodohydroxyquinoline is promising for research in inflammationin, testinal amebiasis, amebic liver abscess and chronic nonspecific diarrheas[1][2][3][4][5].
In Vitro:Diiodohydroxyquinoline (0-10 μM, 72 h) inhibits the viral load, viral antigen expression and infectious viral particle production of SARS-CoV-2, and protected SARS-CoV-2-induced cell damages similar to Remdesivir (HY-104077) in vero E6 cells[3].
In Vivo:Diiodohydroxyquinoline (80 mg/kg, p.o., a single dose for 24 h) exhibits mutagenic activity dose-dependently in mice[2].
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