Lawsone
CAS No. : 83-72-7
| Size | Price | Stock |
|---|---|---|
| 5g | $10 | In-stock |
| 10g | $19 | In-stock |
| 25g | $30 | In-stock |
| 100g | $92 | In-stock |
| 500g | $459 | In-stock |
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| Cat. No. : | HY-N2493 |
| M.Wt: | 174.16 |
| Formula: | C10H6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research[1][2][3][4][5].
In Vitro:Lawsone (125, 250, 500 μM, 18 h) inhibits the growth of Escherichia coli in a dose-dependent manner[3].
Lawsone (0.5, 1, 1.5, 2 mg/mL, 48 h) inhibits cell proliferation in human DLD-1 cells by reducing NF-κB activity, resulting in inhibition of the expression levels of cyclin B1 and cdk1[4].
Lawsone (10, 20, 40, 80, 160 mg/mL, 24 h) has an anti-proliferation effect in SKOV-3 ovarian cancer cells and induces apoptosis by inhibiting Bcl-2[5].
In Vivo:Lawsone (62.5, 125, 250, 500, 750 μmol/kg/day, orally) induces hemolytic reactions associated with oxidative damage of red blood cells in rats[2].
Lawsone (200 mg/mL, orally, for 8 weeks) has a significant inhibitory effect on colon cancer in rats[4].
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